| 1. Identity statement | ||||
| Reference Type | Journal Article | |||
| Site | mtc-m21c.sid.inpe.br | |||
| Holder Code | isadg {BR SPINPE} ibi 8JMKD3MGPCW/3DT298S | |||
| Identifier | 8JMKD3MGP3W34R/3T72D4L | |||
| Repository | sid.inpe.br/mtc-m21c/2019/04.23.18.21 (restricted access) | |||
| Last Update | 2019:04.23.18.21.47 (UTC) simone | |||
| Metadata Repository | sid.inpe.br/mtc-m21c/2019/04.23.18.21.47 | |||
| Metadata Last Update | 2020:01.06.11.42.13 (UTC) administrator | |||
| DOI | 10.3389/fncom.2019.00019 | |||
| ISSN | 1662-5188 | |||
| Citation Key | ProtacheviczBLJIKCSBMABK:2019:BiFiPa | |||
| Title | Bistable firing pattern in a neural network model  | |||
| Year | 2019 | |||
| Month | Feb. | |||
| Access Date | 2024, May 19 | |||
| Type of Work | journal article | |||
| Secondary Type | PRE PI | |||
| Number of Files | 1 | |||
| Size | 4078 KiB | |||
| 2. Context | ||||
| Author | 1 Protachevicz, Paulo R. 2 Borges, Fernando S. 3 Lameu, Ewandson Luiz 4 Ji, Peng 5 Iarosz, Kelly c. 6 Kihara, Alexandre H. 7 Caldas, Ibere L. 8 Szezech Junior, José D. 9 Baptista, Murilo S. 10 Macau, Elbert Einstein Nehrer 11 Antonopoulos, Chris G. 12 Batista, Antonio M. 13 Kuths, Jurgen | |||
| Resume Identifier | 1 2 3 4 5 6 7 8 9 10 8JMKD3MGP5W/3C9JGUT | |||
| Group | 1 2 3 CAP-COMP-SESPG-INPE-MCTIC-GOV-BR 4 5 6 7 8 9 10 LABAC-COCTE-INPE-MCTIC-GOV-BR | |||
| Affiliation | 1 Universidade Estadual de Ponta Grossa 2 Universidade Federal do ABC (UFABC) 3 Instituto Nacional de Pesquisas Espaciais (INPE) 4 Fudan University 5 Universidade de São Paulo (USP) 6 Universidade Federal do ABC (UFABC) 7 Universidade de São Paulo (USP) 8 Universidade Estadual de Ponta Grossa 9 University of Aberdeen 10 Instituto Nacional de Pesquisas Espaciais (INPE) 11 University of Essex 12 Universidade Estadual de Ponta Grossa 13 Potsdam Institute for Climate Impact Research | |||
| Author e-Mail Address | 1 2 3 4 5 6 7 8 9 10 elbert.macau@inpe.br 11 12 13 kurths@pik-potsdam.de | |||
| Journal | Frontiers in Computational Neuroscience | |||
| Volume | 13 | |||
| History (UTC) | 2019-04-23 18:24:30 :: simone -> administrator :: 2019 2020-01-06 11:42:13 :: administrator -> simone :: 2019 | |||
| 3. Content and structure | ||||
| Is the master or a copy? | is the master | |||
| Content Stage | completed | |||
| Transferable | 1 | |||
| Content Type | External Contribution | |||
| Version Type | publisher | |||
| Keywords | bistable regime network adaptive exponential integrate-and-fire neural model neural dynamics synchronization epilepsy | |||
| Abstract | Excessively high, neural synchronization has been associated with epileptic seizures, one of the most common brain diseases worldwide. A better understanding of neural synchronization mechanisms can thus help control or even treat epilepsy. In this paper, we study neural synchronization in a random network where nodes are neurons with excitatory and inhibitory synapses, and neural activity for each node is provided by the adaptive exponential integrate-and-fire model. In this framework, we verify that the decrease in the influence of inhibition can generate synchronization originating from a pattern of desynchronized spikes. The transition from desynchronous spikes to synchronous bursts of activity, induced by varying the synaptic coupling, emerges in a hysteresis loop due to bistability where abnormal (excessively high synchronous) regimes exist. We verify that, for parameters in the bistability regime, a square current pulse can trigger excessively high (abnormal) synchronization, a process that can reproduce features of epileptic seizures. Then, we show that it is possible to suppress such abnormal synchronization by applying a small-amplitude external current on > 10% of the neurons in the network. Our results demonstrate that external electrical stimulation not only can trigger synchronous behavior, but more importantly, it can be used as a means to reduce abnormal synchronization and thus, control or treat effectively epileptic seizures. | |||
| Area | COMP | |||
| Arrangement 1 | urlib.net > BDMCI > Fonds > Produção anterior à 2021 > LABAC > Bistable firing pattern... | |||
| Arrangement 2 | urlib.net > BDMCI > Fonds > Produção pgr ATUAIS > CAP > Bistable firing pattern... | |||
| doc Directory Content | access | |||
| source Directory Content | there are no files | |||
| agreement Directory Content |
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| 4. Conditions of access and use | ||||
| Language | en | |||
| Target File | fncom-13-00019.pdf | |||
| User Group | simone | |||
| Reader Group | administrator simone | |||
| Visibility | shown | |||
| Read Permission | deny from all and allow from 150.163 | |||
| Update Permission | not transferred | |||
| 5. Allied materials | ||||
| Next Higher Units | 8JMKD3MGPCW/3ESGTTP 8JMKD3MGPCW/3F2PHGS | |||
| Citing Item List | sid.inpe.br/bibdigital/2013/10.12.22.16 4 sid.inpe.br/bibdigital/2013/09.22.23.14 3 sid.inpe.br/mtc-m21/2012/07.13.14.45.07 2 | |||
| Dissemination | WEBSCI; PORTALCAPES; SCOPUS. | |||
| Host Collection | urlib.net/www/2017/11.22.19.04 | |||
| 6. Notes | ||||
| Empty Fields | alternatejournal archivingpolicy archivist callnumber copyholder copyright creatorhistory descriptionlevel e-mailaddress format isbn label lineage mark mirrorrepository nextedition notes number orcid pages parameterlist parentrepositories previousedition previouslowerunit progress project rightsholder schedulinginformation secondarydate secondarykey secondarymark session shorttitle sponsor subject tertiarymark tertiarytype url | |||
| 7. Description control | ||||
| e-Mail (login) | simone | |||
| update | ||||